Existing Tools

Comparison tools

Tools used to make comparisons between signatures

Signature enrichment analysis

Compare a selected toxicogenomic signature to the overall set of public signatures

The signature enrichment analysis module allows users to compare a selected toxicogenomic signatures to the overall set of signatures deposited by the community using a distance analysis approach (based on the Euclidean distance and the correlation coefficient).
Creation date May 11, 2020, 12:07 p.m.
Last update May 11, 2020, 12:07 p.m.
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Analysis tools

Tools used to analyze signatures

Functional enrichment analysis

Identify biologicals processes associated with a signature

The functional enrichment analysis allows users to identify biological processes, molecular functions, cellular components and phenotypes significantly associated to a selected signature.
Creation date May 11, 2020, 12:07 p.m.
Last update May 11, 2020, 12:07 p.m.
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ChemPSy tools

Tools interacting with the ChemPSy project

ChemPSy - Spatial prediction

Calculate the distance between a specific signature and the clusters generated by the ChemPSy (Chemical Prioritization System) data

The selected signature and the ChemPSy-defined clusters will be projected on a 2-D axis. Both the Euclidean distance and the correlation coefficient will be calculated for both centroid and medoids
Creation date May 11, 2020, 12:07 p.m.
Last update May 11, 2020, 12:07 p.m.
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ChemPSy - Prediction

Prediction tool using machine learning trained on the ChemPSy (Chemical Prioritization System) data

The aim of ChemPSy (Chemical Prioritization System) is to provide an innovative tool based on several bioinformatics and biostatistics methodologies to analyze and integrate massive toxicogenomics datasets. Specific objectives include: (1) classification of chemicals based on transcriptional signatures, i.e. the set of genes whose expression is known to be positively or negatively altered after an exposure to these compounds; (2) the association of classes with human pathologies or deleterious phenotypes, i.e. classes containing toxicants with well-known effects; (3) the prediction of novel reprotoxicants and/or endocrine disruptors based on transcriptional signature similarities with known chemicals affecting testis development and function.
Creation date May 11, 2020, 12:07 p.m.
Last update May 11, 2020, 12:07 p.m.
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