Superprojects (8) Projects (49173)
TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.
TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.
TSSP3 - Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Among etiological factors of non-alcoholic fatty liver disease (NAFLD), a worldwide epidemic, environmental contaminants have gained importance. Among them, benzo[a]pyrene (B[a]P), a potent environmental carcinogen, in combination with ethanol, was shown to induce the transition of steatosis toward a steatohepatitis—like state both in vitro and in vivo. However, underlying mechanisms ... [more] / May 4, 2021, 10:45 a.m.
TSSP4 - CMap – carcinogenome project
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Jan. 27, 2022, 9:27 a.m.
TSSP5 - CMap – NLT_CALIB
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Dec. 16, 2022, 1:21 p.m.

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TSP731 - Toxicogenomic signatures after exposure to potassium bromate in the human
Public Interventional No description provided TOXsIgN Jan. 28, 2020, 9:53 a.m.
TSP732 - Toxicogenomic signatures after exposure to tacrolimus in the human
Public Interventional No description provided TOXsIgN Jan. 28, 2020, 9:53 a.m.
TSP733 - Triazole Antifungal Toxicogenomics: rat_primary_hepatocyte_CellzDirect
Public Interventional

The triazole antifungals myclobutanil (MYC), propiconazole (PPZ) and triadimefon (TDF) all disrupt steroid hormone homeostasis and cause varying degrees of hepatic toxicity. To identify biological pathways consistently activated across various ...

[more] 		TOXsIgN Jan. 28, 2020, 9:53 a.m.
TSP734 - Expression data from rat tissues dosed with AMG A or AMG B
Public Interventional

To evaluate and characterize gene expression changes and toxicity following oral gavage administration of AMG A & AMG B in male Sprague Dawley rats.

[more] 		TOXsIgN Jan. 28, 2020, 9:53 a.m.
TSP735 - Effect of TCDD Exposure on purified splenic CD8 T cells
Public Interventional

8-12 week, female C57BL/6 mice were injected with 10 µg/kg TCDD or solvent control. CD8+ T cells from spleen were FACS purified and submitted to transcription profiling

[more] 		TOXsIgN Jan. 28, 2020, 9:53 a.m.