The team behind TOXsIgN has invested considerable time, resources, and effort into collecting, curating, processing, developing, and maintaining this web resource. Please follow the citation guidelines if you are using it.
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ...
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Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ...
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TOXsIgN
May 11, 2020, 12:24 p.m.
TSSP3 - Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Among etiological factors of non-alcoholic fatty liver disease (NAFLD), a worldwide epidemic, environmental contaminants have gained importance. Among them, benzo[a]pyrene (B[a]P), a potent environmental carcinogen, in combination with ethanol, was shown to induce the transition of steatosis toward a steatohepatitis—like state both in vitro and in vivo. However, underlying mechanisms ...
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The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ...
[more]
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ...
[more]
tdarde
Dec. 16, 2022, 1:21 p.m.
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TSP741 - Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Human Hepatocytes
PublicInterventional
Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in ...
TSP742 - Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Rat Hepatocytes
PublicInterventional
Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in ...
TSP743 - Pathways identified by toxicogenomics analysis reveal the size and dose independency of silica particles-induced toxicity in mice.
PublicInterventional
Understanding the interactions of nanostructures with biological systems is essential to nanotoxicological research. Using a microarray-based toxicogenomics approach at early stage, this study investigated the relationship between particle size and ...
TSP744 - Gene expression profiles for onset and progression of Cyclosporin A-induced cholestasis in C57BL/6 mice
PublicInterventional
Mechanism-based toxicogenomics (tgx) is used as a tool to identify markers reflective of the onset and progression of cholestasis in C57BL/6 mice using Cyclosporin A (CsA) as a model compound. ...
TSP745 - Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
PublicInterventional
For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics ...