The team behind TOXsIgN has invested considerable time, resources, and effort into collecting, curating, processing, developing, and maintaining this web resource. Please follow the citation guidelines if you are using it.
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ...
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Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ...
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TOXsIgN
May 11, 2020, 12:24 p.m.
TSSP3 - Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Among etiological factors of non-alcoholic fatty liver disease (NAFLD), a worldwide epidemic, environmental contaminants have gained importance. Among them, benzo[a]pyrene (B[a]P), a potent environmental carcinogen, in combination with ethanol, was shown to induce the transition of steatosis toward a steatohepatitis—like state both in vitro and in vivo. However, underlying mechanisms ...
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The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ...
[more]
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ...
[more]
tdarde
Dec. 16, 2022, 1:21 p.m.
There are no superprojects yet.
TSP746 - Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
PublicInterventional
For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics ...
TSP747 - Gene expression profiles of amiodarone, valproic acid, and tetracycline induced steatosis in C57BL/6 mice
PublicInterventional
Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of steatosis in C57BL/6 mice treated by oral gavage using amiodarone (AMD), valproic acid (VPA), and tetracycline (TET). ...
TSP748 - Evaluation of the robustness of classification of carcinogen-modified transcriptomic responses in HepaRG cells and the interlaboratory reproducibility of the model
PublicInterventional
Efforts to develop alternatives which can at least partially replace some of the currently used in vivo tests are ongoing. The recently ended FP6 European project carcinoGENOMICS had the goal ...
TSP749 - Gene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice
PublicInterventional
Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of necrosis in C57BL/6 mice treated by oral gavage using acetaminophen (APAP), isoniazid (INZ), and paraquat (PQ). Critical ...
TSP750 - Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)
PublicInterventional
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. ...